My wife's car has no spare, hasn't been a problem yet but I sure don't like it! Even though I've got roadside service and probably will never remove a wheel on the motorhome myself, I would be very uncomfortable not at least having a spare with me. I understand there are options and many big motorhomes these days don't carry spares, but I like the insurance.
OP, when you say you want to remove the spare for more storage space, I take it the spare is in a compartment and takes up space? Maybe consider moving it to a bumper or rear wall mount or something.
Of course many go with the no spare, carry a credit card plan and it usually works out fine. I just like being as prepared as I can be, so I carry a spare and a credid card and am not afraid to use either lol.