The lug nuts on a Ford E-series chassis are torqued to 140 foot-pounds. That's really not that much more than a normal car or truck. (My little Honda Fit specifies 80 or 90 foot-pounds, for instance.) It doesn't, or at least shouldn't, take a massive impact wrench or five foot breaker bar extension to get them off. I've never had difficulty doing it with the two foot Harbor Freight breaker bar alone (well, with the appropriate sockets and extensions).
A super C built on a heavier truck chassis would likely be a different matter, of course.