HI dukesbone. The advice about camping close to home for the first outing is pretty spot-on. Given that it is almost January, and you're leaving in March for the southland, I think you should plan a driveway campout as noted by others. Most campgrounds in the east are closed, but not all, so the driveway might be it.
What is important is backing into a site, leveling the RV, and hooking up and the reverse. You should be able to do this in your driveway. Learn where to hook up the sewage hose, and how to work the dump valve. By practicing a bit now, it will be easier when you do it for real. Learn how you will communicate with your partner when backing, e.g., what means back-end left, what means stop?
Do you know how to run the genset? Can you operate the hot water heater? (Don't put water in the RV yet, keep it winterized).
Lastly, on your trip south, try to keep to interstates for your first trip. You won't have to worry about low bridges, or narrow lanes (except construction zones). Look for gas stations before you really need it, so if the RV won't "fit" in a station, you can move on. That is one reason why we like to gas up at truck stops. Also, watch for rear-end swing when in tight places like gas pump areas. Good luck on your trip. We are leaving early Feb.