When planning our travels I'll do a cost/time analysis between using a toll road or not. Being a two axle class A towing a two axle daily driver the tolls can be excessive. For most of our travels I have avoided tolls but sometimes it's just not possible. Chesapeake Bay Bridge Tunnel and the Mackinaw Bridge are two that it was more cost effective to pay at the time.
The PA Turnpike I have yet to have a reason to take it considering the alternatives. I80 to the north and I68 to the south for example. I've even run US30 between Breezewood and Bedford to catch I99N to avoid the Turnpike.