It depends on the specific model of the 8.3 engine.
6C8.3 is Naturally aspirated
6CT8.3 is Turbocharged
6CTA8.3 is Aftercooled
C8.3 is Charge air cooled (intercooled).
I would much prefer the C8.3 to the later ISC or ISL. In my opinion, the newer engines have a major flaw - a computer controlled fuel system that like to throw out all kinds of codes. They run great without the computer and are easy to work on. Plus they get better fuel mileage than the computer operated engines. But it is no speed demon going down the highway or climbing hills. But she sure is a good dependable engine without that new fangled computer stuff. The non-computerized 8.3 engine will get you there and back as well and better than the newer ISC and will do it using less fuel.