We've towed a Honda Fit (~2500 lbs) behind the class C Sprinter for about 20,000 miles. Been over the Continental Divide including Monarch Pass a few times, and more recently Utah's "notorious" highway 12 through the Escalante Monument, which reportedly has a few 12% grades. With proper mountain driving it's no problem. The worst of the upgrades are taken in 2nd or 3rd gear at about 45 mph. I consider the downgrades more stressful, because even at 40 mph in 2nd gear, some occasional braking is required. If you drift past the redline going downhill the transmission will do you the "favor" of upshifting to make the situation worse. We haven't pulled the big grades when it was really hot outside so I don't know what would happen to the engine or tranny temp in that case. Your trailer hopefully has its own brakes.