Best I can tell, the only harm 80 PSI rear "might" do in a Class C is worsen the ride, and probably only slightly. Especially since the rear axle ride in a Class C (at least a Ford) is already awful.
65 PSI is max for a Ford Class C through 2007 chassis year. That adds up to their 4600 front axle capacity (GAWR-F). In a 2008 or newer, the 5000 axle calls for 80, again if fully loaded. I installed a 5000 axle (from a 2012) in ours and am at 65 for its 4600 scale weight. Tire shop inflated new fronts to 80 and it was nearly uncontrollable under very adverse conditions. We were going 65 down a concrete-decked bridge (in my experience asphalt tracks better) in a crosswind. I actually stopped on the side of the road to lower the pressure.