What is best tires for e 450 super duty

This like what type is pie is best?
All load range E Light Duty Truck tires are rated by the DOT the same.
Everyone likes something different.

The biggest issue is proper inflation.
Weight you RV after you pick your tires and adjust the pressure to the weight.
If the PSI chart is confusing call the tire company's Customer Service line.

Example:
Using Michelin's chart:
225/75/16E

65 PSI Single (Front) equates to the GAWR of the 4600# front axle E450 used through 2007 (chassis year)
and
75PSI works out to GAWR of the 5000# axle used from 2008 up.


Note Michelin chart has:
Single
60 PSI for single = 2190 lbs
65 PSI for single = 2335 lbs – max 4600 lb. Axle for our year E450

Duel = axle lbs
70 PSI for Duels = 4440 lbs
75 PSI for Duels = 4660 lbs
80 PSI for Duels = 4940 lbs