I have the problem also with my young female Basset Hound (45 lb). Dramamine and Bonine did not work for her, only Cerenia, but on the suggestion of her Vet I have been able to cut the dosage in half with success (60 mg to 30). I plan to try 1/4 pill next. I am hoping she will outgrow the problem. Drs Foster and Smith have the lowest price that I have found. My vet matched that price because I am a very frequent visitor. We are starting out on a 6 week trip this week and I have 7 boxes of Cerenia. We will be going through the mountains and I understand that mountainous travel provokes motion sickness. Hoping for some luck with this because I don't want to see her suffer.