She made the entire trip lying in the back seat with my wife and pretty much unable to see anything outside. She began severe drooling before I even started the engine but managed about an hour, until we got on some rough and curvy, country roads. We made it to within about three miles of our destination. Dogs react to an upset stomach almost like a human. Throwing up is accompanied by drooling and slobbering.
The interesting thing was that the Travel Calm didn't seem to have an effect. The when she lost it we found out why. The chopped up pill and the chunk of cheese we had melted it into still in one chunk. That was a good three hours after we gave it to her.
I have seen a lot of products recommended here and appreciate everyone, but for now it seems that getting the medicine digested into her system is job one.