Thanks, all. Jesse's already on a grain-free diet. Been to the vet numerous times. We have finally figured out that he "blossoms" exactly when the pollen starts in full force. I'd love to keep him in during peak pollen times, but that's when he gets out because both of us work during the day. Bedding does get washed but probably not often enough. We also treat topically.
Dr. Doug, I had come across Apoquel when I was doing net research on causes/cures. Up until this year, he hadn't really be itchy. My vet also brought it up but he hadn't started the itchies yet. Will try 50mg of Benedryl twice a day to see if it helps. May also try the apple cider vinegar wash which has also been recommended. Will keep everyone posted!