We had a Husky/Sheppard mix that went through the same thing. It started with urination and progressed to defecation. We both worked days and the dogs favorite spot to lay was on a hassock that came with our living room furniture. The poor dog would lay there all day in her own urine. After numerous vet visits we had a family discussion about quality of life. We all decided we wouldn't want to live like that. It was a sad day. I took her in myself and we shared a cheeseburger on the way. She was in my arms when she crossed over to a better place.