Soresto Collar Danger
Found this article on issues with Soresto collars: https://whdh.com/news/popular-flea-collar-for-pets-linked-to-nearly-1700-deaths-documents-show/ I had heard rumors of issues in the past but neve...
Forum Discussion
I have been wondering if these reported adverse reactions are due to genetics of the impacted animal.
In reading up on how these slow release collars and spot-on treatments work I came across statements about how on cats certain active ingredients (or formulations) are not as effective as on dogs because the adsorption through the skin of the active ingredients is faster in cats than dogs lowering the amount of the drug on the skin of the cat to kill flees and ticks.
I then browsed the literature for transdermal drug delivery in humans (i.e. nicotine patch) and came across studies on the impact of certain genetic mutations that alter how fast drugs are absorbed from the patch to the blood stream.
These literature findings suggest to me that it is possible there are canine mutations that alter how fast drugs on the skin (via spot-on or slow release collars) are absorbed through the skin and if this process is fast enough the serum levels could become high enough to become toxic.
In reading up on how these slow release collars and spot-on treatments work I came across statements about how on cats certain active ingredients (or formulations) are not as effective as on dogs because the adsorption through the skin of the active ingredients is faster in cats than dogs lowering the amount of the drug on the skin of the cat to kill flees and ticks.
I then browsed the literature for transdermal drug delivery in humans (i.e. nicotine patch) and came across studies on the impact of certain genetic mutations that alter how fast drugs are absorbed from the patch to the blood stream.
These literature findings suggest to me that it is possible there are canine mutations that alter how fast drugs on the skin (via spot-on or slow release collars) are absorbed through the skin and if this process is fast enough the serum levels could become high enough to become toxic.
