Just because you mentioned being one-handed ...
Do you know about sticky keys? It's a setting that allows you to 'hold down the Ctrl key' just by tapping it. It's a keyboard setting under Accessibility. You can also turn it on by tapping the Shift key 5 times. You'll see this message.
Do you want to turn on Sticky Keys?
Sticky Keys lets you use the SHIFT, CTRL, ALT, or Windows Logo keys by pressing one key at a time. The keyboard shortcut to turn on Sticky Keys is to press the SHIFT key 5 times.
Disable this keyboard shortcut in Ease of Access keyboard settings