No to be a stick in the mud, all Garmins (GPS's in general) are RV friendly. Some might add a feature or 2 that add some additional options but otherwise they are all great.
I recently updated to the Garmin 2797 (one of the new 2013 series) with 7" screen and voice control (We can't reach our GPS when driving). It's also lifetime maps and traffic. I have not used the traffic option much but coming from the OR beaches back to Albany the GPS suddenly popped up and said an accident had been reported on I-5. Shortly it showed a 23 min. delay on our current route and provided optional routing. By the time we were close to the detour "she" reported a shorter delay which made the original route most likely the best.