I have owned both also. We started with motorhomes and then went 5er. As you are looking at new 5er's you can ignore the big difference in set up times as that is a thing of the past. Most new 5ers come with automatic levelers so your big difference here is instead of leveling from your drivers seat you get out of your truck and push button on trailer. Both MH and 5er have to unhook from truck or towed so that is a wash as is power, water and sewer. I would also ignore the old way of thinking that it makes a difference how often you will be moving as most MH and campers sit during the winter months with no harm to either.
Both my last mh and current 5er are 37ft with 3 slides, More room in our 5er with floor plan.
Things I miss about MH.
Huge windshield
DW use bath while driving
Not getting out in rain to go to bathroom. But really this has never happened to us but it could I guess.
Things I don't miss about Mh
Cost of tires and up keep on running gear. I can replace tires on 5er about 4 times for cost of 1 set for mh. Both last about the same.
Fuel mileage.
Tag cost for us in Ga. at the time.
Cost of insurance.
Looking up high at tv. Personal thing.
You can buy a pretty nice 5er for about half of what a comparable gas Mh.
Keep in mind a lot of folks here will compare that low $50K 5er a $300k DP.
We will never go back to a mh but that is our preference. Bottom line for you is try to take everything in consideration and get what best suits you.
I agree with another poster here if you are looking at huge 5er's you need more truck than a 2500.