Perhaps I can give an objective opinion, considering I have never owned a 5er or a MH. I'm a happy TT owner, so let me chime in.
I think it boils down to only 2 factors in what one needs when it comes to a 5er or a MH. It's really this simple:
The ability to separate truck and trailer and use each independently
or
The ability to move around inside when traveling
Break camp every time you need to go an an excursion
or
Leave camper behind and do those excursions in a separate vehicle
If you factor in ONLY a MH vs a 5er, these are the main issues.
If you factor in a TOAD for the MH, the "separation" factor is not an issue, but the overall cost is.
YOU have to decide which is more important for your needs.
(I choose TT because I did not want to give up the bed of my truck and wanted the "separation" availability. I don't mind not having access to the refrigerator when driving. That what rest stops are for).