Our first travel trailer, a 20 footer, purchased new back in '94, had a cornered bed with a small slice off one corner. Sounds a bit weird, but we were younger then (40s), it was our first camper after tent camping for 20+ years so we were just happy to get off the ground. Our bedding didn't fit well with one corner lopped off. We'd just crawl over one another to get in and out.
Our next camper was a 5th wheel with a queen walk around bed. It made a big difference and was more like home.
If this is your first RV and you're going to spend a lot of time in it then I'd make sure my bed was very comfortable and easy to access. Other posters have pretty much described the issues with layout and how the mattress might rest upon a storage area. But if you're handy with woodworking you might be able to make the necessary adjustments. If it's just you in the bed then all the easier, but 2 adults in a bed limit your options.
