Well, this is why I asked the question. I know my limits of driving, but that was just in an 18 wheeler and my pickup going across country. Pulling a camping trailer with 4 passengers, thats why I asked. I really appreciate all the responses and will go back to the other two adults here and reconsider what we want to do for the trip. I was able to find a few slots at a couple KOA campsites for the days mentioned, which is why I started pursuing this route. I am thinking long term here too, planning future trips, and spur of the moment weekenders. Weighing all factors as well.
The #1 thing, I cannot give up my F150 for this. It is my daily driver, and one of the most comfortable vehicles, save for the Flex, I have driven. Getting 20+ MPG doesn't hurt either.
I blame my wife for this, I got a nice bonus this year, her reaction, OOH family trip to Disney Oh H e l l N O!!! Grand Canyon popped into my head, and that's where I am at now. Mainly I hate crowds, and would like to get away from people for a while. It's too bad the resort I went to when growing up is long gone, would love to do that at least one more time.
Thanks for all the responses, your experience doing this is what I was looking for, and helps me make my decision easier.