We full-timed and traveled constantly and the refrigerator was always on. No problem.
For the freezer we always re-packaged the big packages of meat into smaller portions. We didn't use the freezer for snacky-type items such as ice cream, pizzas, t.v. dinners, etc. It just held meats and frozen vegetables. We could load it with 21 days of meals and it wasn't a residential refrigerator. We also didn't have an ice-maker which takes up a lot of room.
If you're just going for a weekend for a typical 2 or 3-week vacation, then plan your meals on paper so you'll have the staples along with you. As stated, grocery stores are everywhere - even in Alaska!