I've been RVing solo since 1991. Any problems I have encountered have had nothing to do with gender.
If you live alone, you know how it is. You are the housekeeper and the vehicle manager. You have to take care of every task or hire someone else to do it. Same on the road.
Solo travelers of either gender have no extra set of eyes, no one to carry the spare keys, no relief driver, etc. They have to learn to compensate, the same as people who live alone have to learn to deal with that.
I've been camping all my life. My first solo trip was 24 hours at a familiar campground. I was watching every second click by until I could go home. Fast forward a few years and quite a few new skills, I was boondocking way out there and delighted to not see or hear any people or vehicles for over two days.
Go for it! Happy travels to you!