On some part of a final 300 mile leg going home, I picked up a HUGE nail in one of the inside rear duals. But it stayed in the tire, creating a slow leak instead of a blow out. When I checked the air pressures the next morning, that tire read "zero". Since I didn't know if I picked it up leaving the CG or when I pulled into my storage building, I slowly drove up to my dealer and had all four rear tires replaced. And a TST TPMS system installed on the RV and toad. As we all know, with flat tire(s) we're just driving sleds.
I did once have a blowout on the right front tire of the Jeep toad, and the TPMS informed me immediately. Some idiot backed into it. The idiot was me.