with two batteries you are half as likely to have dead batteries. lol. Assuming that they are healthy batteries of course.
Two is more power, more amps, and less chance the lights will flicker when the water pump comes on.
The downfall is that with two 12's they need to be matched and about the same age. If one is a little more gone than the other then it will always be pulling voltage off the slightly better one and the better one will always be drained down to the lesser charge. Thus the 6-volt in series solution.
If you use solar then this mitigates the problems greatly.
Personally I have two 12 volt systems that can be connected together, but I keep em apart. One is dedicated for the electric cooler fridge/freezer, the other for the coach. I can be without coach power, but that fridge has to stay running. Im sure there are other good reasons to keep batteries separated too.