I run mine set to the rear. I'm not sure what the effect is on the front axle weight, but it does not feel light. With a long bed, double cab truck I doubt that it offsets the weight of the diesel engine.
With the GM puck mounts reversing the base in the mounts will set the arms either forward or rearward, the Ford looks to be the same. Try it, I doubt it will drive any different which ever way are arms set.
What you will gain is clearance with the tailgate down, and a little more angle before hitting the overhang with the bed corners.