General observation from an engineer.
"Blowouts" are basically an improperly diagnosed Run Low Flex Break which results from a tire being operated at speed while significantly under-inflated or more likely actively leaking. TPMS will most likely provide sufficient warning to prevent RV damage.
Tread separations are basically caused by a failure of the rubber around the belt edges. This rubber can loose it's strength through being overheated which artificially accelerates the aging process which results in lower strength as does basic "old age".
Overheating occurs when a tire is overloaded, under-inflated or run at a high rate of speed.
Doing a "Free Spin" tire inspection can find indications, such as out of round or side to side "wobble", which indicate potential separation. before the tire comes apart. Doing this inspection annually or every few month on multi-axle trailers might alert owners to the need to replace a tire