I have been tossing this around in my mind & trying to put myself in your DW's position. I am not sure what experience she has behind the wheel of a large vehicle like that with blind spots unlike a standard vehicle but for me, it is very little. I think I would be more comfortable making a trip like that after I had quite a bit of experience in me and take a shorter trip this year. That is just me. She may jump in the drivers seat & take off like a champ but she may feel more intimidated behind that wheel in traffic than she may think. Also another thing to consider, for us the drive home seems to always be more exhausting than the trip out, you may find yourself needing a vacation from the vacation if you push too many miles on the way home & need to get back to work soon. Just a thought.