Wife here: Because of DH's work schedule, I usually do the driving, setup and takedown with our MH, and he comes on the weekend with the car. I much prefer driving to being a passenger. Prior to the MH I had only driven cars and pickups.
I started driving the MH in a factory parking lot on the weekends, then went to quiet back roads, then through town with traffic. Scared shaking at first, honestly, but one does get over that kind of quickly. One complaint: the driver's seat is built for someone larger than me in every way. The seat is too deep so I have a pillow behind my back. Also the seat is too high so my heel doesn't touch the floor when my foot is on the gas pedal. That really strains the knee hour after hour.
DH tried to teach me to back a trailer once -- it was down a ramp to a loading point. After about thirty tries, I got out cussing and walked away. He's smart enough to never have asked me to back a trailer again. Best wishes!