Weight impacts fuel mileage most when you are constantly going up and down grades.
Aerodynamics impacts fuel mileage ALL the time.
The 20% increase you describe might be a best case. Looking at pictures/ the design of the two trailers - I'd expect at least 9-12% better fuel mileage.
We joke about getting 15 mpg on a trip to the Rio Grande Valley from Dallas - 7 mpg going down there and 8 mpg coming back. Wind is usually on our nose going down.
I've seen my fuel mileage cut by 30% driving head into a 35 mph wind. Had to be at a specific location at a specific time for a major commitment - otherwise I would have pulled over and waited.