A couple of questions that may help people respond: How old are you? Do you plan on working while on the road?
We were lucky enough to retire in our 40's and went full time one month later - January 2014. We spent the six months before retiring renovating the house and purging it of things we didn't need or want. In one room, we piled the things we couldn't get rid of (photos, etc) and in another, things we were going to take with us. Every couple of weeks, we would move both piles of stuff. This helped us realize how much everything we were keeping weighed and how much space it took up. Over six months, our piles got smaller and smaller; we had been living with less and less and much of it was unnecessary stuff.
Amazing moments?
Seeing two grizzly bears play on the gravel beds at the foot of Salmon Glacier.
Watching the sunset over the Sonoran Desert.
Driving the White Rim Road in Canyonlands.
Kayaking in the Gulf of Mexico to Shell Key.
Photographing a meteor shower over the Badlands.
And those are just a few I could name off the top of my head.
Best wishes with your plans. The break is very freeing if you go into it with both feet and are well prepared.