Well, I would say it depends first on your overall health. After that, if you're both healthy then it comes down to convincing yourself mentally that "you can do it."
Me n my wife, we're 45y/o and as I type this on our 23rd anniversary today, my wife has had uhhhh 10? At least heart surgeries or procedures including a couple open hearts, a thorocotomy, half dozen heart caths and some other surgeries like a pericardial window.
Suffice it to say, if she wants to live, she can't be out of range of her cardiac team.
However she's totally healthy right now (comparatively speaking) and would go anywhere we wanted to head.
2 years ago, 2 months after most of a year in the hospital, we packed up the kids and camper and took off for a month. If SHTF in BFE somewhere, her opinion was better then sitting at home worrying about it.
IMO if you DO have serious health issues, it's more time to go live life and not sit at home if you're able.
Heck, even if full timing, we could drive back to Seattle and park the RV there.
Guess it depends on how you want to live life.
Me, I'd take off across the tundra with a backpack and a rifle tomorrow. If I get eaten by a grizz or die of a heart attack or fall off a cliff.....whatever. I was living life while I was around.
BTW, we'll be pulling the boat out for the first time tomorrow and $20 says my wife is drinkin ciders and probably take a rip on the wakeboard or surfboard.
After going through this with her...I/we learned time is precious. Go do what you want to while you can and don't worry about the little stuff.