Cool!
Yeah depends how comfortable you are with making "plans" on the fly and if your part of the rv park crowd or willing to use your rv as a true mobile home, i.e., ok with stopping for the night wherever and sleeping.
As far as on the road reservations, popular destinations and holiday weekends need to be considered heavily for reservations, but I personally couldn't stand have each and every days location planned out for weeks on end.
Just check some of the destination areas and ask how they fill up and make reservations accordingly when necessary. Lat big trip we took X country, had reservations in Yellowsotne (like a month ahead) and near MT Rushmore. Everywhere else between WA and WI and back was day by day. Which is super easy now becasue you can figure where to head and where to stay in real time, sitting in the passenger seat doing 70 across Kansas.
Bottom line, don't be apprehensive. Have your house buttoned up however you need to, tow rig and rv in good shape for travel, whatever that means to you, load your stuff, fill the fridge and let er rip. There's grocery stores, gas stations and campgrounds in every town. You're not going "away" to a deserted island, your spending a day in other people's home towns and somehow they survive there, so betting u can too!