New England (Cape Cod)to Florida in Feb

I use the method paulcardoza posted above although on a Sunday morning I would use I-95 over the GWB. Driving west there is no toll. Anytime before noon is an easy drive and I have never had a problem with the wind or trucks going over the GWB. I used this method when I lived in the Fall River - New Bedford area and I will use it when I leave Newport, RI in November. When I head north I will use the Tappan Zee bridge because it's always after noon when I get to that area and the toll is cheaper also.

Going west I take GWB early in morning during week days or anytime in morning on weekends then 80 west or 76 west depending on traffic to I81 south. On the return trip I take I 81 north to I 84 over Newburgh bridge and continue on I 84 to home. This eliminates the NJT tolls and GWB tolls and traffic.

I'd say 81 has more, steeper grades. Better views, too. 95 from New York to Fredericksburg, VA is a fluster cluck. Take your pick.
Often, most of the time, coming out of the Virginia side of D.C. suburbs, we go West on Route 66 to 81, then head towards 75 to get to Ft. Myers (went to High School there). Usually, Route 95 is like punishment and is to be avoided. I'll happily motor a half hour longer through the country side than sit in traffic, watching people pick their nose and sucking exhaust.
I've also had to go to Texas via West Virginia when leaving Virginia in mid-February to get around a snow storm. Nothing we can do about the weather. Shoot for the Shenandoah Valley, and bring your cork screw, just in case.