I think once she gets some miles under her belt with a car in tow, she'll find she's adapted to it. A good rear view camera on continuously can be a big help.
An "all-terrain" style tow bar, such as the ReadyBrute models and others, can make hooking up and unhooking a much simpler process where the terrain and angle are less of a factor. A one-armed friend of ours made a lightweight support out of PVC tubing that he uses to hold his tow bar arms in position while he connects the pins. Something like that would likely be helpful to your wife as well. Or you could assist her with hooking up by supporting the arms while she aligns and pins them.