I went from a 2000 Tundra to a 2011 (1st generation to 2nd gen) and ended up going through a complete re-adjustment of my Equal-i-zer. Had to change the height (2011 2nd gen is lower--go figure), ball angle (I'm now at pretty much the maximum ball tilt) and sway bar bracket height. I even moved the sway bar brackets farther back on the trailer in order to get more leverage on the bars.
The 2nd gen Tundra (at least the TRD version) has a much stiffer suspension that the 1st gen, and it takes more leverage to transmit the proper amount of weight to the front wheels.
An old thread here suggested that Toyota doe not recommend adjusting according to Equal-i-zer's instructions regarding obtaining the same amount of "settling" with weight on the Equalizer. I elected to stick with Equalizer's recommendations and adjusted for close to the same amount of "settling" on front and rear axles.
I had LT tires on the 1st gen and the 2nd gen trucks--wouldn't tow without them.
Tows great now!