My previous truck was a 15 GMC 2500 that I did just a basic cognito torsion bar level with longer UCA's and Icon shocks with external reservoir front and back. That truck rode REALLY well, but I never towed anything other than a flatbed with a SxS in back.
This truck I have a 4" CST suspension lift (4 in the front, 2 in the rear) with the Fox 2.0 pro shocks and it rides terrible compared to my 2500. Any washboard type bumps are incredibly jarring. I'm not sure if it's the shocks, the lift itself, or both. Could partly be from going to a 3500 from a 2500 too. Maybe it's just stiffer all around. It's even more stiff with the toyhauler on it, but I suppose that's to be expected when you have all that weight compressing things.
But yeah, other than the rear end oscillating up and down a few times over larger bumps, the truck seemed to handle it fine. I averaged about 63 mph, but got as high as 70 and never felt like I was fighting for control. Handling, braking and power all felt really good. The tow mode seemed to keep it in low gear going down grades and the exhaust brake really helped keep the speed under control. I feel much better after towing it a good distance. High cross-wind will be the next big test I suppose.