Tireman9 answer to the same question of going to a E tire from a D tire. In part he says;
** He will gain a safety margin if he increases his inflation to 65psi with LR-D but if he stays at 65psi there is nothing further gained by going to LR-E as there is no difference in the capacity at 65psi.
The same thing would apply to the 22.5 example. When we look at the Goodyear tables we see that at 110psi both the LR-G and the LR-H are rated for 6,175# single or in dual application at 100psi they both are rated as 5,675#.**
And in his rvtiresafety blog on speed rating in part says;
**You will gain nothing from a Load Range change if you do not also increase the air pressure.**
Its been my experience if the D tires have plenty of reserve load capacity above actual scaled wheel load weights then nothing is gained with a E tire at 65 psi.
Having hauled for a living I never heard of using less than sidewall pressures in a tire on a trailer till I started hanging out on rv forums.
Goodyear says in their "weighing a RV website"
clicky linkGoodyear Tire and Rubber .... weighing RVs
Special Considerations
**** Unless trying to resolve poor ride quality problems with an RV trailer, it is recommended that trailer tires be inflated to the pressure indicated on the sidewall of the tire. Trailer tires experience significant lateral (side-to-side) loads due to vehicle sway from uneven roads or passing vehicles. Using the inflation pressure engraved on the sidewall will provide optimum load carrying capacity and minimize heat build-up.***
Now if the D tires load rating doesn't have the proper capacity or proper reserve load capacity then the E tire at 80 psi will be a good upgrade.