Fuses vs. circuit breakers: there's no inherent reason to always prefer one over the other in my opinion. Probably circuit breakers are a little handier in most situations.
Fuses are generally less expensive and often smaller in size, but obviously cannot be reset. Circuit breakers can be reset and (depending on the type) can also be used as a disconnect switch. Either one, properly sized for the wire, will safely prevent overcurrent in the case of a short circuit or overload and so keep the wire from getting too hot and potentially starting a fire, which is of course their primary purpose.