Having serviced everything from Honda 600s to Wisconsin V4 37.5 horsepower prime movers at altitudes to 11,200 ft. (Saddlebag Lake) my opinion about the necessity of reducing jet orifices is not glowing.
I had difficulty in discerning any difference in power. No reduction in exhaust smoke. But I did re-set to reduce oil contamination and improve spark plug life.
Using a "scale" of total improvements with prime movers with adjustable initial timing, the aggregate total of timing and jets was estimated to be 97% timing and 3% re-jetting. On a high altitude only service pickup I fitted 12.5 to 1 compression pistons and that modification amounted to at best only a modest increase in power. By far turbocharging with a waste gate or supercharging made significant power gains.
As a side note I successfully was able to use regular gasoline in the service truck.
I wish you the best of luck