The Handi is louder (7-8 db louder than the 140 lb. EU3000iS), costs more, and puts out less power than both a pair of Honda EU2000i's and EU3000iS.
I know that, according to the specs, the Handi is louder but in reality there doesn't seem to be much difference.
I have the original EU3000is and a friend has the Handi. We had our RV's side by side and both ac units were being run. I really had difficulty detecting a difference. The both run at about the same lower pitch than the 1000 and 2000 series, which, to me, makes them more pleasant to be around.