Are we talking about flex-related damage to the panel due to air lift and RV roof vibrations, or damage to the roof after panel flew off due to air lift?
Don't want to brag, but it will take a real hurricane to rip my 250W panels off the roof. 4 legs at each corner, 4-6 #10 screws per leg, and I made sure that most screws would hit the rafters. Panel surface is 3.5"-4.5" above the roof. Flex has no role in this, IMO. It's all about number of screws (and legs). Last 2 hurricanes in Mexico didn't leave a trace - though I've seen panels ripped off the roof on some homes nearby.
I would be more concerned about damage to glass cover due to flex of the panel on the road, but then again, it's easy to reinforce the frame. Hitting the rafters would be a bonus here as well. Forget double-sided tape or caulk, you need stainless hardware if you want it to hold. I used caulk (Dicor) only as a sealant under the legs.