The tuners work on Diesels very well, or did. I'm not familiar with units with all the emissions hdwe.
We had a 2002 F350 Dualie Diesel with a tuner bought from Dealer. I caan't pull up the nae of the tuner right now.
It had three settings, tow haul, and two performance settings. I left it on the tow setting. It improved power tremendously and mileage. Ran like a race car when empty.
Diesels like fuel compression and timing. They have reduced compression and fuel for emissions. Power is n so they upped size just a bit, which really didn't amount to much.
A Tuner should increase timing and fuel. Timing will help compensate for compression somewhat also.
The more you feed a diesel the greater the output and efficiency or mileage but you can burn the pistons up if too hot. They can swallow all the air you can feed them. They don't have throttle bodies.
I don't remember why they tune to certain levels when the engines can put out more except emissions.
If I can find an 06 back Cumminsin a Dodge or Ford o4 back 7.4 International, in the Ford I'll will buy it. The older Duramax, do good also.
Performance or power and mileage come last in the EPA's plans for emissions.