I hauled a 12ft Caribou on a 1991 F250 with my family of 6 for about 12 years. The truck was loaded and a dually would have been more comfortable in turns. We drove a little slower and it did fine. My truck had the gas engine, 2wd, factory extra overload springs, the slide in camper package and was a supercab, not crew cab. I did frequently tow a 4,000lb boat behind it and kept up to 4 bicycles on a front carrier. We always started with a full tank of fresh water. I do not recommend travelling with the grey water tank over half full if yours is like mine at the very back of the camper floor.
If you put on air bags keep them on separate channels for stability and leveling.