I agree with the idea of going right to a full size. We've mostly had Suburbans. We had a mid-size SUV for 8 years and I'm so glad we went back to a full size truck.
We have an '08 Sierra, my mom and her husband last year bought a '14 Silverado. Love these trucks. My wife loves driving ours. And mileage isn't that bad either. I get 17 in the city pretty easily and it's just the 4 speed, and my mom is getting pretty much the same. It's going to depend a bit on driving style. As a daily driver we find it just as practical as any other vehicle we've ever owned.
Yes, compare to an F150, Tundra, and a RAM. We found out of all of them the Silverado/Sierra and F150 interiors were the most comfortable. Out of the 4 the Tundra seems really outdated on the inside. The RAM has a beautiful interior but uncomfortable seats. But that's my take on it.