E tires will make tire flex a non part of the equation. Up to 80psi vs 40-50psi means you can make them up to 100% stiffer than P tires.
And yes it’s noticable.
But it may not be necessary. I rountinely run cheap OE P truck tires with trailers.
Fwiw 50psi + in even a 44 psi rated tire pressure will not hurt the tire. I have to use up the P rated tires on every new work truck I get and usually set the rears at 50-55psi because I’m always carrying a load in the bed and frequenstly towing. Never had a problem but D or E tires are good peace of mind and add stability and tire capacity.