I have had a PUP twice, a 26ft TT, and now I'm going back to a PUP.
For me the advantages of a PUP (and this is how it relates to an A frame) are that due to its smaller size, you tend to not spend as much time in them. Giving your camping experience a more "camping" feel. Now that mother nature has reclaimed my TT, we decided to go back to a PUP because we missed the more out in the open feel of a PUP. We found ourselves in the trailer more than we should have (for us). Yes, we could have concentrated on staying outside, but when the ease and comfort are there, sometimes you just find yourself in there.
Properly matched and set up TV/TT shouldn't be difficult or stressful to drive. Either small, medium, or large. Shouldn't be that big of a deal. So for us, how we used it meant a lot more. Plus we can get it to more remote campsites, which we missed with the larger TT.
Many other considerations, but that was number 1 for us. When we retire, we'll go back to a TT because much of our traveling will be site seeing or visiting relatives vs camping.
So like most things, clearly define how you plan to use it, buy the one you like, and have fun.