I asked Toyo about going lower than the min pressure with weight on their chart, which was 80 psi (245/70R19.5 M608z LRG). They said I could go to 70 psi, but that was as low as I should go based on the bead staying seated. 19.5's, well any .5" tire, needs more pressure to stay seated. I have run them at 50 rear and 70 rear with no noticeable change in ride, 70 is as low as I go.
My front axle is actually lighter when towing than empty, but I like the high pressure for stability. I run 70/70 empty and ~78/94 when towing. 94 just happens to be where my pressure switch on my OBA cuts out. I will probably change it higher, but 94 is plenty of air for my weight. 95 psi is good for 4080 lbs, and so far the heaviest I have been on the rear tires is ±3600lbs.