FWIW, something to consider beyond "when will it run out" and "when do I have to stop for the facilities" is what you're towing and how that impacts where you are when either of the two above criteria kick in.
I had an F350 towing a 39' 5th wheel. Stock tank was (IIRC) 34 gallons. Enough to go as long as was really practical. However, with the biga** trailer, I had to start looking for suitable stations (generally meaning truck stops) at about the 1/2 tank level. This became a real pain the behind, particularly if traveling on secondary roads, and after having to unhook the trailer and run the truck to a station one midnight, it became worth the $$ to add a auxiliary tank.
I went with an in-bed extra 70 gallon tank and it was great. For the next 5-8 years (until the end of the RV chapter of life), I didn't have to stop at all during the "day" but could simply fill up the truck and aux tank once I was stopped for the evening and had parked the trailer.