I personally don't think the floor plan would be an issue. Getting to the bathroom and the frig is the most important on trips. So you may have to run the kitchen slide out a little to open the frig, no biggie. I wouldn't let that be a deal breaker if you like the model.
However here's a few things to think about.
One, as IdaD said, that's getting on up there in weight for your Suburban. Tongue weight could realistically be in the 1100-1200lb range.
Two, don't pack the entire house, some of those models don't leave much room for cargo weight. You'll be surprised how fast things add up.