I run the max pressure in my tires. I also filled them with Nitrogen. This made quite a bit of difference in the pressure build up while driving. There has been a reduction of approx. 4 # per tire after a couple of hours at highway speeds.
I did this as I was concerned about the pressure building up while driving. I had heard the nitrogen would help with this and it does.
The ride is a bit more harsh with the tires totally inflated. However, I do not worry about being able to carry the load. As a bonus with the nitrogen, I do not have to adjust (add) near as often.