As I recall the ResMed required a DC-DC converter while the Respironics simply needed a DC cord. Every invertor and converter used lessens efficiency and causes unneeded battery drain. I use the Respironics System One without the humidifier. The manual cautions the device should not be used when the vehicle supplying DC is running to avoid damage. Since the electronics of the device are always on, I put a switch on the DC outlet I installed. I confess I sometimes fail to turn off the switch prior to travel, but have experienced no damage.